Makassar Natural Product Journal (MNPJ)

UJI AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE TERHADAP EKSTRAK ETANOL UMBI LOBAK (Raphanus sativus L.) SECARA IN VITRO

DWI ISRANANDA — 2024-09-25

Antioxidant Activity Test of Ketapang Leaf Extract (Terminalia catappa L.) Using the B-Carotene Bleaching Method

Vega Wati — 2024-09-25

Ketapang (Terminalia catappa L.) is a plant that belongs to the Combretaceae family which is spread in tropical countries, including Indonesia. Ketapang leaves (Terminalia catappa L.) contains flavonoid compounds which function as antioxidants. The purpose of this study was to determine the antioxidant activity of ketapang leaf extract (Terminalia catappa L.) using the β-carotene bleaching method. The extract was obtained through the maceration method, then the yield percentage was 20.25%. Phytochemical screening test was carried out identifiy chemical compounds and obtained namely alkaloids, flavanoids, tannins, saponins, and steroids. Antioxidant activity was performed using UV-Vis spectrophotometry with a wavelength of 538 nm. The results showed that the antioxidant activity of ketapang leaf extract (Terminalia catappa L.) of 56.5% was an intermediate antioxidant (moderate), then in a standard solution of quercetin has a strong antioxidant activity of 72.3%.

Keywords : Ketapang leaves (Terminalia catappa L.), Screening Phytochemicals, Antioxidants, B-carotene bleaching, Spectrophotometry UV-Vis.

ANTIOXIDANT ACTIVITY TEST OF TURI (Sesbania grandiflora L.) LEAF EXTRACT USING β-CAROTENE BLEACHING METHOD

Salsabilah Lutfiah — 2024-09-25

Turi Leaf (Sesbania grandiflora L.) belong to the fabaceae family that contain flavonoids as an antioxidants. The antioxidants have free radical scavenging properties that can inhibit the oxidation of free radicals. It is used to protect the skin from oxidative damage and to prevent premature aging. This research aimed to determine the antioxidant activity of turi leaf extract by b-carotene bleaching method. The leaves were extracted using macerations method, the yield percentage of 16,685 %. Quantitative analysis by UV-Vis spectrophotometry at the maximum wavelength of 538 nm. The results showed that the antioxidant activity of the turi leaf extract is 50.7% which is intermediate antioxidant, then in quercetin standard solution.

Keywords : Turi Leaves (Sesbania grandiflora L.), Antioxidant, β-carotene bleaching, UV-Vis spectrophotometry

STANDARDISASI EKSTRAK ETANOL BIJI BAGORE (Caesalpinia crista L.).

Ardiansa Ardiansa — 2024-09-25

Bagore plant (Caesalpinia crista L.) belongs to the tribe Leguminosae and grows wild on the coast. Standardization is important to guarantee potency uniformity benefits by ensuring the concentration of active ingredients through qualitative analysis of secondary metabolites, ensuring the safety and stability aspects of extracts and increasing the economic value of extracts by various analyses such as specific and non-specific parameters. This study aims to standardization bagore seed extract (Caesalpinia crista L.) and determine the value of specific and non-specific parameters of. Samples were obtained from Binuang District, Polewali Mandar Regency, West Sulawesi Province, macerated with 96% ethanol then standardized with specific and non-specific parameters. The results of the study obtained specific parameter values as follows; organoleptic tests obtained extracts in the form of viscous, light brown in color, characteristic smell and very bitter taste; The content of soluble compounds in water is 14.361%; the content of soluble compounds in ethanol is 15.708%; positively contains flavanoid compounds, alkaloids and saponins; and the value of non-specific parameters as follows: drying shrinkage which is 0.439%; specific weight of 0.859 grams; moisture content of 2.589%; total ash content of 4.216%, insoluble ash content of acid which is 0.630%; The mold number is < 1.0 x 101 colonies/ml and the yeast is < 1.0 101 colonies/ml; lead metal contamination (Pb) is 0.003 g / g and cadmium (Cd) is 0.01 g / g. Research shows bagore seed extract (Caesalpinia crista L.) provides results according to the general standard parameters of medicinal plant extracts.

Keyword : Bagore seed, Caesalpinia crista L., standardization, spesific parameters, non-spesific parameters.

Studi In Silico Prediksi Sifat Fisikokimia dan Toksisitas Senyawa Tectoquinone Sebagai α-Glukosidase inhibitor

Ahmad Najib — 2024-09-25

Tectoquinone is a chemical compound from natural ingredients in the Syzigium oblanceolatum (C.B.Rob) plant. Previous research has proven that Tectoquinone has antidiabetic activity by inhibiting the α-glucosidase enzyme. This research on physicochemistry and toxicity aims to determine the feasibility of tectoquinone if used as an oral drug in silico using the pKCSM Online Tool. The results obtained are that tectoquinone has fulfilled the physicochemical test with parameters based on the Lipinski Rule of Five. However, the results of the toxicity test showed that tectoquinone had ames toxicity, hepatotoxicity, and the LD50 value obtained was 468.92 g/kg.

REVIEW ARTIKEL Formulasi Sediaan Farmasi Kasumba Turate

Nurul Mujahida Munir — 2024-09-25

Tanaman kasumba turate (Carthamus tinctorius L.) merupakan obat tradisional yang digunakan oleh masyarakat. Berdasarkan beberapa penelitian tanaman ini memiliki khasiat sebagai antioksidan dan imunostimulan. Kandungan kimia dari tanaman ini diantaranya adalah flavonoid, feniletanoid glikosida, kumarin, asam lemak, steroid, dan polisakarida. Karena memiliki banyak khasiat, tanaman ini telah dikembangkan menjadi sediaan-sediaan farmasi yang lebih modern. Penelitian ini bertujuan untuk mengetahui dan mengkaji informasi terkait penelitian yang telah dilakukan mengenai pengembangan formula sediaan kasumba turate (Carthamus tinctorius L.). Penelitian ini menggunakan pendekatan studi literatur dengan menggunakan Google Scholar dan Pubmed sebagai sumber data dan memilih artikel berdasarkan kriteria yang telah ditetapkan peneliti.

Berdasarkan pencarian, diperoleh sebanyak 6 artikel. Terdapat beberapa rancangan formulasi bentuk sediaan farmasi tanaman kasumba turate (Carthamus tinctorius L.) diantaranya sirup (larutan), emulsi, granul, granul effervescent, mikroemulsi dan pengembangan bahan baku dalam bentuk nanopartikel.

FORMULASI DAN EVALUASI SEDIAAN BODY CREAM EKSTRAK ETANOL BUAH ALPUKAT (Persea Americana Mill) SEBAGAI PELEMBAB

Sarima Amalia Maharani — 2024-09-25

Moisturizers are very popular dermatological products prescribed because they have been proven effective for preventing and treating a variety of dermatological conditions. Moisturizer products have a vital role for skin health to ensure the skin remains hydrated for both normal and dry skin by increasing the water content in the stratum corneum, so that it is able to moisturize the skin. Avocado fruit (Persea americana Mill) can hydrate the skin because it contains chemicals such as vitamin A, vitamin E, fat, carbohydrates, folic acid and protein. This research aims to formulate and interpret the physical stability of avocado ethanol extract body cream preparations as a moisturizer. This type of research is laboratory experimental. The stages of this research began with extraction, formulation, and ended with evaluation of body cream preparations. This research obtained results that body cream preparations can be formulated as moisturizers by mixing the emulsion form and gel form of the formula ingredients with the effective concentration of carbopol 940 in the body cream preparation of avocado fruit ethanol extract being 0.7% (Formula 2) because this concentration is higher. physically stable and more popular with the panelists. This research can be concluded that the pH and homogeneity tests show that all formulas are stable, the viscosity test shows that there is instability due to storage temperature in formula 3, the spreadability and stickiness tests show that formula 1 is unstable to changes in storage temperature, the hedonic test shows that the panelists prefer the formula 2, and moisturizing effectiveness testing shows formula 3 provides the greatest moisturizing effect.

Moisturizer adalah produk dermatologis yang sangat populer diresepkan karena terbukti efektif untuk mencegah dan mengobati berbagai kondisi dermatologis. Produk moisturizer memiliki peran yang vital bagi kesehatan kulit untuk menjamin kulit tetap terhidrasi baik untuk kulit normal maupun kering dengan cara meningkatkan kadar air dalam stratum korneum, sehingga mampu untuk melembabkan kulit. Buah Alpukat (Persea americana Mill) dapat menghidrasi kulit dikarenakan memiliki kandungan kimia seperti vitamin A, vitamin E, lemak, karbohidrat, asam folat, dan protein. Penelitian ini bertujuan untuk memformulasi dan menginterpretasi stabilitas fisik sediaan body cream ekstrak etanol buah alpukat sebagai pelembab. Jenis penelitian ini yaitu eksperimental laboratorium. Tahapan penelitian ini dimulai dengan ekstraksi, formulasi, dan diakhiri dengan evaluasi sediaan body cream. Penelitian ini memperoleh hasil bahwa sediaan body cream dapat diformulasikan sebagai pelembab dengan cara mencampurkan antara bentuk emulsi dan bentuk gel dari bahan formula dengan konsentrasi efektif karbopol 940 pada sediaan body cream ekstrak etanol buah alpukat adalah 0,7% (Formula 2) dikarenakan konsentrasi ini lebih stabil secara fisik dan lebih digemari oleh panelis. Penelitian ini dapat disimpulkan bahwa pada pengujian pH dan homogenitas menampilkan semua formula stabil, pengujian viskositas memperlihatkan adanya ketidakstabilan akibat suhu penyimpanan pada formula 3, pengujian daya sebar dan daya lekat menunjukkan formula 1 tidak stabil terhadap perubahan suhu penyimpanan, pengujian hedonik menunjukkan panelis lebih menyukai formula 2, dan pengujian efektivitas pelembab menunjukkan formula 3 memberikan efek pelembab terbesar.

REVIEW ARTIKEL: KARAKTERISTI DAUN ALAMANDA

Tajram Tajram — 2024-09-25

Alamanda (Allamanda cathartica L) merupakan salah satu genus dari famili Apocynaceae yang berasal dari Brazil di Amerika Selatan. Famili ini terdiri dari sekitar 1000 spesies yang tergolong dalam 75 genus yang tersebar didaerah tropika. Tanaman allamanda ini ditemukan di wilayah dengan ketinggian 10-850 m diatas permukaan laut. Secara alamiah, alamanda tergolong tumbuhan perambat dengan tinggi dapat mencapai 6 m, berbuku-buku, bercabang dan bergetah di mana tumbuhan alamanda di indonesia banyak di gunakan sebagai obat secara turun temurun . Tujuan review artikel ini untuk mengetahui karakterisasi dan penetapan kadar pada daun alamanda sebagai obat tradisional , metode yang digunakan adalah metode riview jurnal yang di ambil 10 tahun belakang , di mana pada daun alamanda memiliki metabolit sekunder seperti flavonoid , steroid tanin dan saponin , maka dari itu alamanda banyak memiliki khasiat seperti, obat sembelit, demam, bisul, kurap

Kata kunci: Daun Alamanda; karakteristik; Allamanda cathartica L

REVIEW ARTIKEL : KARAKTERISTIK DAUN KEMIRI (Aleurites moluccana L.) SEBAGAI OBAT TRADISIONAL

FITRIANI M — 2024-09-25

Kemiri Merupakan Tanaman yang tergolong kedalam famili Euphorbiaceae, sebagai tanaman rempah. Tanaman kemiri biasa tumbuh liar pada ketinggian 150-1000 m di atas permukaan laut. Tanaman kemiri dapat hidup di daerah beriklim subtropis dan tropis dengan curah hujan 640-4290 mm, tetapi lebih dominan tumbuh pada iklim tropis lembab dengan curah hujan 2000 mm atau lebih. Tanaman kemiri tersebar di seluruh daerah Indonesia karena Indonesia merupakan kepulauan beriklim tropis. Daun kemiri yang muda berbentuk seperti delta atau oval, berwarna keputihan kemudian berubah menjadi warna hijau saat daun tua dan pada permukaan daun terdapat bulu halus (pilous). Tujuan review artikel ini untuk mengetahui karakterisasi dan penetapan kadar pada daun alamanda sebagai obat tradisional , metode yang digunakan adalah metode riview jurnal yang di ambil 10 tahun belakang. Daun kemiri mengandung senyawa metabolit sekunder di antara lain Alkaloid, Flavanoid, Tanin, Saponin, Fenolik dan steroid. Daun kemiri juga memiliki sifat analgesik, antivirus dan anti bakteri yang dapat membantu meningkatkan sistem kekebalan tubuh. Daun kemiri Secara empiris bisa digunakan untuk pengobatan bisul, sakit kepala, demam, diare, hipokolesterolemia, anti-inflamasi dan anti piretik.

PERBANDINGAN KADAR SINEOL DARI MINYAK KAYU PUTIH PRODUKSI TRADISIONAL DAN MODERN

Sri mayang usman mayang usman — 2024-09-25

ABSTRACT

Eucalyptus oil is an oil that has been commonly used in the lives of Indonesian people. Eucalyptus oil is an essential oil obtained by distilling the leaves and twigs of the eucalyptus plant. Eucalyptol (1,8-Sineol) is a monoterpene compound that has anti-inflammatory and antioxidant properties. Usually used to treat airway disorders. This study aims to identify the comparison of sineol content of eucalyptus oil from traditional and modern production. This research method was carried out using densitometry and GC MS. The results obtained in densitometry clusters are the highest levels of sineol in the eucalyptus leaf comparator, namely 451.2%, while in eucalyptus oil there is traditional eucalyptus oil (ambon), namely 198.7%, whose sineol content is higher than the modern eucalyptus oil sineol content, which is 67.13%. For the results obtained on GC-MS, the highest level of sineol in traditional eucalyptus oil (ambon) is 52.65% compared to modern eucalyptus oil which is 32.11% and also the comparison of eucalyptus leaves which is 0.28%.

Keywords : Eucalyptus oil; traditional; modern; sineol ; KLT Densitometro; GC-MS.