LITERATURE REVIEW : Uji Molekular Docking Senyawa Osimertinib Beserta Turunannya Terhadap Reseptor Tirosin kinase Pada kanker Paru- Paru
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Abstract
Lung cancer is all malignancy in the lung, including malignancy originating from the lung itself (primary). In clinical terms, what is meant by primary lung cancer is a malignant tumor originating from the bronchial epithelium. Current anti-lung cancer therapy has the goal of inhibiting the activity of EGFR. One of the substances that inhibits the action of EGFR is Tyrosine Kinase Inhibitor (TKI). Osimertinib has the potential to inhibit the phosphorylation of cells containing EGFR mutations. This review article aims to determine the ability of osimertinib compounds and their derivatives as lung cancer therapeutic agents against tyrosine kinase receptors using the molecular docking method. The research method used is literature review using two databases, namely Pubmed and Google Scholar for the last 10 years from 2013-2023. And the results obtained are that Osimertinib can be used as a lung cancer therapeutic agent against tyrosine kinase receptors
References
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[2]. Purohito. Buku ajar primer: ilmu bedah toraks, kardiak, dan vaskular.
Surabaya: Airlangga University Press; 2016. h.50-61.
[3]. Kusumawardhani, Arline Rahmadianti, et al. Target Aksi Obat Gefitinib Pada Reseptor Tirosin Kinase Terhadap Penyakit Kanker Paru. Jurnal Pendidikan dan Konseling (JPDK), 2022, 4.6: 9017-9023.
[4]. Liu, Tie-Cheng, et al. Role of epidermal growth factor receptor in lung cancer and targeted therapies. American Journal of Cancer Research, 2017, 7.2: 187.
[5]. Zhang, Haijun. Osimertinib making a breakthrough in lung cancer targeted therapy. OncoTargets and therapy, 2016, 9: 5489–5493
[6]. Fauziah, Anisa, et al. Molecular Docking Senyawa Yang Berpotensi Sebagai Antikanker Payudara: Literature Review. Journal of Pharmaceutical and Sciences, 2023, 6.2: 416-427.
[7]. Pinzi, L., & Rastelli, G. (2019). Molecular Docking : Shifting Paradigms in Drug Discovery. International Journal of Molecular Sciences, 20(18), 4331.
[8]. Syahputra, G., Ambarsari L and T, S. (2014) ‘Simulasi docking kurkuminenol, bisdemetoksikurkumin dan analognya sebagai inhibitorenzim12 lipoksigenase’, Biofisika, 10(1), pp. 55–67
[9]. Shoichet, Brian K., et al. Structure-based discovery of inhibitors of thymidylate synthase. Science, 1993, 259.5100: 1445-1450.
[10]. Ewing, Todd JA; KUNTZ, Irwin D. Critical evaluation of search algorithms for automated molecular docking and database screening. Journal of computational chemistry, 1997, 18.9: 1175-1189.
[11]. Ahmad, S., Singh, S., Srivastava, M. R., Shukla, S., Rai, S., & Shamsi, A.
S. Molecular Docking Simplified: Literature Review, 2021, 4.4: 37-44 [12]. Rarey, Matthias, et al. A fast flexible docking method using an incremental
construction algorithm. Journal of molecular biology, 1996, 261.3: 470-
489.
[13]. Danziger, D. J.,Dean, P. M. Automated site-directed drug design: a general algorithm for knowledge acquisition about hydrogen-bonding regions at protein surfaces. Proceedings of the Royal Society of London. B. Biological Sciences, 1989, 236.1283: 101-113.
[14]. Agarwal S, Chadha D, Mehrotra R. Molecular modeling and spectroscopic; 2015
[15]. Huey, Ruth; Morris, Garrett M.; Forli, Stefano. Using AutoDock 4 and AutoDock vina with AutoDockTools: a tutorial. The Scripps Research Institute Molecular Graphics Laboratory, 2012, 10550.92037: 1000.
[16]. Al Huda, Bayu Herdi, et al. Docking molekuler senyawa b-karoten dalam tanaman kelor (Moringa Oleifera L.) Sebagai penghambat enzim tirosinase dengan autodock vina. Jurnal Insan Farmasi Indonesia, 2020, 3.2: 230-240.
[17]. Muttaqin, Fauzan Zein; Ismail, Halim; Muhammad, Hubbi Nasrullah. Studi molecular docking, molecular dynamic, dan prediksi toksisitas senyawa turunan alkaloid naftiridin sebagai inhibitor protein kasein kinase 2-Α pada kanker leukemia. Pharmacoscript, 2019, 2.1: 49-64.
[18]. PEBRIANA, Ratna Budhi, et al. Docking Kurkumin Dan Senyawa Analognya Pada Reseptor Progesteron: Studi Interaksinya Sebagai Selective Progesterone Receptor Modulators (SPRMs). 2012.
[19]. Rena, Suci Ramda; Nurhidayah, Nurhidayah; Rustan. Analisis Molecular Docking Senyawa Garcinia Mangostana L Sebagai Kandidat Anti SARS- CoV-2. Jurnal Fisika Unand, 2022, 11.1: 82-88.
[20]. Komari, Noer; Adawiyah, Rabiatul; Suhartono, Eko. Evaluasi Molecular Docking Senyawa Mangiferin Dari Buah Kasturi (Mangifera Casturi) Sebagai Antikanker Payudara. In: Prosiding Seminar Nasional Lingkungan Lahan Basah p-ISSN. 2022. p. 1611.
[21]. Pratama, Mohammad Rizki Fadhil. Studi Docking Molekular Senyawa Turunan Kuinolin Terhadap Reseptor Estrogen-Α: Study of Molecular Docking of Quinoline Derivative Compounds against Estrogen-A Receptors. Jurnal Surya Medika (JSM), 2016, 2.1: 1-7.
[22]. Suherlan, Sintya; Rohayah, R.; Fakih, T. M. Uji Aktivias Antikanker Payudara Senyawa Andrografolida Dari Tumbuhan Sambiloto (Andrographis paniculata (Burm F) Ness.) Terhadap Human Epidermal Growth Factor Receptor 2 (HER-2) Secara In Silico. Jurnal Ilmiah Farmasi Farmasyifa, 2021, 4.2.
[23]. Torres, Leydis Luna; Puentes, Neyder Contreras; Amador, Antistio Avíz. Virtual screening of Osimertinib and Dacomitinib Analogues with potential activity on EGFR (T790M and l858R Mutations) for non-small cell lung cancer treatment. Revista Ciencias Biomédicas, 2021, 10.4: 234-245
[24]. Mishiro, Kenji, et al. Development of radiohalogenated Osimertinib derivatives as imaging probes for companion diagnostics of Osimertinib. Journal of Medicinal Chemistry, 2022, 65.3: 1835-1847.
